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Organoids: a new window into disease and development - Detailseite

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  • Online Belegung noch nicht möglich oder bereits abgeschlossen
Grunddaten
Veranstaltungsart Q-Team Veranstaltungsnummer 21811691
Semester WiSe 2021/22 SWS 2
Rhythmus keine Übernahme Moodle-Link  
Veranstaltungsstatus Freigegeben für Vorlesungsverzeichnis  Freigegeben  Sprache englisch
Belegungsfrist - Eine Belegung ist online erforderlich
Veranstaltungsformat Digital

Termine

Gruppe 1
Tag Zeit Rhythmus Dauer Raum Raum-
plan
Lehrperson Status Bemerkung fällt aus am Max. Teilnehmer
Mi. 10:00 bis 12:00 wöch 20.10.2021 bis 17.02.2022      findet statt     1000
Gruppe 1:
Zur Zeit keine Belegung möglich


Zugeordnete Personen
Zugeordnete Personen Zuständigkeit
Karaiskos, Nikolaos verantwortlich
Pentimalli, Tancredi Massimo verantwortlich
Zuordnung zu Einrichtungen
Einrichtung
Universitätsverwaltung, Studienabteilung (I), Administration Qualitätspakt Lehre, bologna.lab
Inhalt
Kommentar

Organoids are 3-dimensional, miniaturized and simplified versions of organs. They are produced through the differentiation of stem cells in vitro and are to replicate part of the complexity of their in vivo tissues. Organoids have been gaining attention in the last 10 years, after the development of several protocols that enable their reproducible and stable growth. These include brain organoids, but also colon, stomach, kidney and other tissues.

Organoids hold the promise of replacing traditional animal model systems to a large degree. First, organoids derived from human stem cells have the potential of modeling human diseases and capturing biology at a more accurate level than other model systems. A prime example comes from the study of the Zika virus: scientists employed human brain organoids to study the effects of the infection upon the human brain development causing microcephaly. Second, organoid models are emerging as a way to reduce the numbers of animal models, - such as mice - that today need to be sacrificed in order to understand and
treat human diseases, therefore paving the way for more ethical and sustainable science.

In this Q-team the students will use state-of-the-art tools to analyze single-cell RNA sequencing datasets and explore organoids stemming from different tissues, and/or within a disease state. The main research task will be to identify whether the chosen organoids recapitulate the cell type composition and the complexity of their native in vivo tissues with accuracy and reproducibility in health and disease. The students will form teams to study an organ and disease of choice and will leverage publicly available datasets and dataset integration tools to compare organoids with human references from large-scale, international studies (e.g. the Human Cell Atlas). The Q-team will include students from both biological and computational backgrounds to work on these questions.

Registration for the Q-team is handled through the lecturers
- nikolaos.karaiskos@mdc-berlin.de
- tancredimassimo.pentimalli@mdc-berlin.de
In your registration request, please provide information on your academic background and on your programming skills.

Bemerkung

5 ECTS can be acquired in the seminar. Classes will start on 20 October 2021 and will take place on Wednesdays at 10:00.

Zielgruppe

The Q-team is open to Bachelor and Master students from life sciences, quantitative, or interdisciplinary fields (Biology, Medicine, Computer Science, Physics, Mathematics, Bioinformatics, or similar). Basic programming skills in python or R are required.

Q-team participants will have the opportunity to gain research experience with basic practices of scientific work, including working in an interdisciplinary team, getting familiar with analyzing biomedical datasets and documenting the outcomes of the scientific work. The course will be entirely held in English.

Registration for the Q-team is handled through the lecturers
- nikolaos.karaiskos@mdc-berlin.de
- tancredimassimo.pentimalli@mdc-berlin.de
In your registration request, please provide information on your academic background and on your programming skills.

Strukturbaum

Keine Einordnung ins Vorlesungsverzeichnis vorhanden. Veranstaltung ist aus dem Semester WiSe 2021/22. Aktuelles Semester: SoSe 2022.
Humboldt-Universität zu Berlin | Unter den Linden 6 | D-10099 Berlin